ORM1 MEDIATES OSTEOBLAST/OSTEOCLAST CROSSTALK IN ADOLESCENT IDIOPATHIC SCOLIOSIS VIA RANKL/OPG RATIO ALTERATION

ORM1 mediates osteoblast/osteoclast crosstalk in adolescent idiopathic scoliosis via RANKL/OPG ratio alteration

Adolescent idiopathic scoliosis (AIS), a complex early-onset three-dimensional spinal deformity, remains etiologically ambiguous despite extensive ongoing investigations.Currently, braces and surgeries are primary treatments of AIS, which come with inherent risks and costs.Therefore, there is an urgent need for biotherapeutic targets for AIS.Using

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How Temperatures May Affect the Synthesis of Fatty Acids during Olive Fruit Ripening: Genes at Work in the Field

A major concern for olive cultivation in many extra-Mediterranean regions is the adaptation of recently introduced cultivars to environmental conditions different from those prevailing in the original area, such as the Mediterranean basin.Some of these cultivars can easily adapt their physiological and biochemical parameters in new agro-environment

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In Vivo Preclinical Assessment of the VEGF Targeting Potential of the Newly Synthesized [52Mn]Mn-DOTAGA-Bevacizumab Using Experimental Cervix Carcinoma Mouse Model

Among humanized monoclonal antibodies, bevacizumab specifically binds to vascular endothelial growth factor A (VEGF-A).VEGF-A is an overexpressed biomarker in cervix carcinoma and is involved in the development and maintenance of tumor-associated neo-angiogenesis.The non-invasive positron emission tomography using radiolabeled target-specific antib

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